Exploring the principles behind antibiotics with limited resistance

The study suggests that dual targeting of antibiotics is not enough to prevent bacterial resistance. Only those that target membrane integrity and block another cellular pathway show reduced resistance development. The study tested three antibiotic candidates, POL7306, Tridecaptin M152-P3, and SCH79797, and found that resistance evolution against these antibiotics is limited in ESKAPE pathogens. The study provides guidelines for future antibiotic development.